3-Phenylpyridine → 3-Phenylpyridin-2-amine

HRID 1658506Notes

Reaction equation

HRID 1658506 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2-:13].[Na+]>>[NH2:13][C:8]1[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:12][CH:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 138863-PhenylpyridineHCID 24533Sodium amide

Product 1

HCID 27627953-Phenylpyridin-2-amine

Procedure

2-Amino-3-phenylpyridine is prepared by reacting 46.5 g. 3-phenylpyridine with 11.7 g. of sodium amide at a temperature of 250° in the presence of mineral oil. The 2-amino-3-phenylpyridine that is formed is purifed by distillation and is substituted for the 2-amino-4-phenylpyridine in Example 8 to obtain the named compound.

Workup

  1. custom2-Amino-3-phenylpyridine is prepared
  2. customat a temperature of 250°

Sources & evidence

ORD record
ord-e44c6ce050e842c38e7ea1dad8dccada
Source dataset
uspto-grants-1976_06
Patent number
US03965100

Reaction notes

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