Phenethylamine → 2-Phenylethylamine hydrochloride

HRID 1658596Notes

Reaction equation

HRID 1658596 reaction equation
[Cl:1]C1C=CC(OC)=C(C=1)C(Cl)=O.[CH2:13]([NH2:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1C=CC=CC=1>[ClH:1].[CH2:13]([NH2:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 123841765-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 90752-Phenylethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

5-Chloro-2-methoxybenzoyl chloride (15g.), dissolved in benzene, was added slowly to a solution of phenethylamine (18 g.) in benzene. Phenethylamine hydrochloride formed was filtered off, and the benzene removed from the filtrate. The residual oil was distilled to give an oil (19.4 g., 90%) b.p. 205° at 0.2 mm., which crystallized on standing m.p. 60°-63°.

Sources & evidence

ORD record
ord-d9dba61bbd8e46a5aa91ddc19d9e826a
Source dataset
uspto-grants-1976_06
Patent number
US03965173

Reaction notes

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