O-Cresol → 4-Methylphenyl phosphorodichloridate

HRID 1658654Notes

Reaction equation

[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].CN1[CH:11]=[CH:10]N=C1.[C:12]1(C)[C:17]([OH:18])=[CH:16][CH:15]=C[CH:13]=1>>[P:1]([Cl:5])([Cl:3])(=[O:2])[O:18][C:17]1[CH:12]=[CH:13][C:10]([CH3:11])=[CH:15][CH:16]=1

Participants

Reactant 3

HCID 335O-Cresol

HCID 13901-Methylimidazole

HCID 24813Phosphorus oxychloride

Product 1

HCID 2489054-Methylphenyl phosphorodichloridate

Procedure

To a mixture of 225 g. phosphoryl chloride and 1.6 g. 1-methylimidazole there is added 109 g. cresol over a period of 2 hours at a temperature of 105°C. The temperature is held at 105°-110°C. for two hours to afford cresyl phosphorodichloridate.

Workup

additionTo a mixture of 225 g

Sources & evidence

ORD record: ord-0181926d508440bc98adaac1b2ad15df
Source dataset: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03965220

Reaction notes

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