反应详情

2.3 g. of 11β-fluoro-4-androstene-3,17-dione is stirred under reflux in 25 ml. of tert.-butanol and 15 ml. of ethylene chloride with 4 g. of chloranil and 50 mg. of p-toluenesulfonic acid for 6 hours. After the reaction mixture has been worked up as described in Example 16 and chromatographed on silica gel with acetone/hexane, 1.2 g. of 11β-fluoro-4,6-androstadiene-3,17-dione is obtained. UV: ε280 = 25,600.

1. temperatureunder reflux in 25 ml
2. customchromatographed on silica gel with acetone/hexane, 1.2 g