Potassium Carbonate → HCID 21393400, compound

HRID 1658733Notes

Reaction equation

HRID 1658733 reaction equation
C(=O)([O-])[O-].[K+].[K+].[Cl-].[NH2:8][C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Br:23]>C(O)CC>[NH:8]=[C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N:10]1[CH2:15][S:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[Br:23]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 21393395HCID 21393395, compound

Product 1

HCID 21393400HCID 21393400, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

To a suspension of 13.8 g of anhydrous potassium carbonate in 150 ml of anhydrous n-propanol is added 33.1 g of 2-amino-1-[[(o-bromophenyl)thio]methyl]pyrimidinium chloride, portionwise, under nitrogen, at room temperature, with stirring. Subsequently, the mixture is stirred and heated under reflux for 2 hours, filtered hot, and the filtrate concentrated in vacuo. The residue is partitioned between 200 ml each of water and ether, the ether layer is separated, dried, and concentrated to give about 28.7 g of the named compound, after recrystallization from pentane.

Workup

  1. stirringSubsequently, the mixture is stirred
  2. temperatureheated
  3. temperatureunder reflux for 2 hours
  4. filtrationfiltered hot
  5. concentrationthe filtrate concentrated in vacuo
  6. customThe residue is partitioned between 200 ml each of water and ether
  7. customthe ether layer is separated
  8. customdried
  9. concentrationconcentrated

Sources & evidence

ORD record
ord-3c50fab355ca4defabe140d17b1754c7
Source dataset
uspto-grants-1976_06
Patent number
US03966733

Reaction notes

Loading…