Hydrochloric Acid → HCID 21526455, compound

HRID 1659077Notes

Reaction equation

HRID 1659077 reaction equation
[OH:1][CH:2]([CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:17]([C:27]#[N:28])[CH:16]=1)[C:3]([O:5]CC1C=CC=CC=1)=[O:4].Cl.[H][H]>[Pd].[C].C(O)(=O)C>[OH:1][CH:2]([CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[C:17]([C:27]#[N:28])[CH:16]=1)[C:3]([OH:5])=[O:4]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 21526370HCID 21526370, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 21526455HCID 21526455, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 0.01 moles of benzyl α-hydroxy-γ-(3-cyano-4-cyclohexylphenyl)butyrate dissolved in 100 ml. of acetic acid and containing 0.01 mole of hydrogen chloride is shaken with hydrogen over a 5% Pd carbon catalyst until 0.01 moles of hydrogen is absorbed. The catalyst is then filtered and the solution is evaporated to dryness and crystallized to obtain α-hydroxy-γ-(3-cyano-4-cyclohexylphenyl)butyric acid.

Workup

  1. customis absorbed
  2. filtrationThe catalyst is then filtered
  3. customthe solution is evaporated to dryness
  4. customcrystallized

Sources & evidence

ORD record
ord-82cc959c4f1e4dd0ad4dee2c24c1b75a
Source dataset
uspto-grants-1976_06
Patent number
US03966801

Reaction notes

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