Hydrochloric Acid → HCID 18362786, compound

HRID 1659119Notes

Reaction equation

HRID 1659119 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH:15](Cl)[CH3:16])[CH2:11][CH2:10]1.Cl.[CH3:19][NH2:20]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][NH:20][CH3:19])[CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 18360105HCID 18360105, compound

Product 1

HCID 18362786HCID 18362786, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8 ml of ethanol were added to a mixture of 8.9 g of 4-(o-methoxyphenyl)-1-chloroethyl-piperazine .HCl in 20 g of an aqueous solution of 34.88% methylamine and the mixture was stirred for 1 hour at room temperature and then for 4 hours at reflux. The ethanol was evaporated and after cooling the mixture, 5 g of sodium hydroxide pellets were added thereto. The mixture was extracted with ethyl ether and the extracts were dried over potassium carbonate and the solvent was evaporated. The oily residue was distilled to obtain 2.6 g of 4-(o-methoxyphenyl)-1-(β-methylaminoethyl)-piperazine in the form of a yellow oil boiling at 153°C under 0.2 mm Hg. The oil was soluble in ethanol and ethyl ether and slightly soluble in water.

Workup

  1. temperaturefor 4 hours at reflux
  2. customThe ethanol was evaporated
  3. temperatureafter cooling the mixture, 5 g of sodium hydroxide pellets
  4. additionwere added
  5. extractionThe mixture was extracted with ethyl ether
  6. dry with materialthe extracts were dried over potassium carbonate
  7. customthe solvent was evaporated
  8. distillationThe oily residue was distilled

Sources & evidence

ORD record
ord-f9e1c5a2ae1a4a69902784b072f317dd
Source dataset
uspto-grants-1976_06
Patent number
US03966950

Reaction notes

Loading…