反应详情

Sodium hydride (0.7 g., 80% w/w suspension in mineral oil) was added gradually to a stirred solution of 1-[4-(4-chlorophenyl)phenyl]ethanol (4.7 g.) in dry dimethylformamide (20 ml.), keeping the temperature below 40° C. After 30 minutes stirring ethyl 2-bromopropionate (2.6 ml.) was then added, keeping the temperature below 30° C. After stirring for 16 hours at room temperature, the mixture was poured into water (150 ml.), and the subsequent mixture was extracted with ether. The combined extracts were washed with water, dried (MgSO4) and evaporated to give ethyl 2-{1-[4-(4-chlorophenyl)phenyl]ethoxy}propionate, as an oil (3.0 g.).

1. customthe temperature below 40° C
2. additionwas then added
3. customthe temperature below 30° C
4. extractionthe subsequent mixture was extracted with ether
5. washThe combined extracts were washed with water
6. dry with materialdried (MgSO4)
7. customevaporated