Cysteamine Hydrochloride → HCID 131712297, compound

HRID 1659586Notes

Reaction equation

HRID 1659586 reaction equation
[OH:1][N:2]([CH2:4][C:5]1[O:9][C:8]([CH2:10]O)=[CH:7][CH:6]=1)[CH3:3].[ClH:12].[NH2:13][CH2:14][CH2:15][SH:16]>Cl>[ClH:12].[ClH:12].[NH2:13][CH2:14][CH2:15][S:16][CH2:10][C:8]1[O:9][C:5]([CH2:4][N:2]([OH:1])[CH3:3])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 9082Cysteamine HydrochlorideHCID 20559455HCID 20559455, compound

Product 1

HCID 131712297HCID 131712297, compoundYield 125.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5-[[Hydroxy(methyl)amino]methyl]-2-furanmethanol (7.85 g) was added to a stirred solution of 2-aminoethanethiol hydrochloride (5.68 g) in concentrated hydrochloric acid (15 ml) at 0° during 45 mins. After 48 hr at 0° the crystalline solid which separated was mixed with isopropanol (40 ml), filtered and crystallised from ethanol to give the title compound (9.1 g) m.. 164°-165° dec.

Workup

  1. customAfter 48 hr at 0° the crystalline solid which separated
  2. additionwas mixed with isopropanol (40 ml)
  3. filtrationfiltered
  4. customcrystallised from ethanol

Sources & evidence

ORD record
ord-199b78c34d2946c193d5f26aa1a8cfc7
Source dataset
uspto-grants-1981_12
Patent number
US04304780

Reaction notes

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