Hydrochloric Acid → HCID 12783825, compound

HRID 1659876Notes

Reaction equation

HRID 1659876 reaction equation
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][N:4]=1.[NH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][OH:23].[ClH:24]>O>[ClH:24].[ClH:24].[OH:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][NH:17][C:3]1[NH:8][C:7](=[O:9])[C:6]([CH2:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 756345-Aminopentan-1-olHCID 127838233-Pyridylmethyl-2-methylthio-4-pyrimidone

Product 1

HCID 12783825HCID 12783825, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Methylthio-5-(3-pyridylmethyl)-4-pyrimidone (23.3 g) and 5-aminopentanol (24.5 g) were fused together at 170°-180° for 2 hours. Water was added to the cooled residue and the mixture was adjusted to pH7 with dilute hydrochloric acid. The solid (23.8 g) which crystallised out was recrystallised from 2-propanol containing hydrogen chloride to give 2-(5-hydroxypentylamino)-5-(3-pyridylmethyl)-4-pyrimidone dihydrochloride, m.p. 203°-205°.

Workup

  1. customThe solid (23.8 g) which crystallised out
  2. customwas recrystallised from 2-propanol
  3. additioncontaining hydrogen chloride

Sources & evidence

ORD record
ord-e3dbeba4e66a4fd3a33b56a887a7cb61
Source dataset
uspto-grants-1981_12
Patent number
US04305945

Reaction notes

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