Tris(hydroxymethyl)aminomethane → HCID 20558494, compound

HRID 1659903Notes

Reaction equation

HRID 1659903 reaction equation
[C:1]([O:13]C)(=O)[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[CH:4][CH:3]=1.[CH2:15]([OH:22])[C:16]([NH2:21])([CH2:19][OH:20])[CH2:17][OH:18]>CO>[OH:22][CH2:15][C:16]([NH:21][C:6](=[O:8])[C:5]1[CH:4]=[CH:3][C:2]([C:1]([NH:21][C:16]([CH2:19][OH:20])([CH2:17][OH:18])[CH2:15][OH:22])=[O:13])=[CH:11][CH:10]=1)([CH2:19][OH:20])[CH2:17][OH:18]

Participants

4

Reactant 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 8441Dimethyl terephthalate

Product 1

HCID 20558494HCID 20558494, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 1-liter, three-neck, round-bottom flask equipped with a thermometer, stirrer and condenser were placed 194 g (1.0 mole) of dimethyl terephthalate, 242 g (2.0 mole) tris(hydroxymethyl) aminomethane and 1 liter of methanol. The mixture was refluxed for 8 hours and then allowed to cool. The title compound crystallized and was removed by filtration and dried. The melting point was 188°-190° C.

Workup

  1. customIn a 1-liter, three-neck, round-bottom flask equipped with a thermometer, stirrer and condenser
  2. temperatureThe mixture was refluxed for 8 hours
  3. temperatureto cool
  4. customThe title compound crystallized
  5. customwas removed by filtration
  6. customdried

Sources & evidence

ORD record
ord-58090bf1824d41e9b4ee1eabe42cbcbe
Source dataset
uspto-grants-1981_12
Patent number
US04305868

Reaction notes

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