反应详情

To a solution containing 150 ml of isopropanol and 4.8 g (0.025 mole) of 3-o-methoxyphenoxypyrrolidine was added, with stirring, 6.15 g (0.025 mole) of 4-chloro-2-phenylquinazoline. The reaction was exothermic and the mixture refluxed for 15 min. The temperature subsided to room temperature and, after standing at room temperature for 11/2 hr, the resulting reaction mixture was filtered. The crystalline solid was recrystallized with isopropanol. Yield of product was 1.9 g, m.p. 142°-144° C.

1. additionwas added
2. temperaturethe mixture refluxed for 15 min
3. customsubsided to room temperature
4. customafter standing at room temperature for 11
5. custom2 hr
6. customthe resulting reaction mixture
7. filtrationwas filtered
8. customThe crystalline solid was recrystallized with isopropanol