Hydrochloric Acid → HCID 86738161, compound

HRID 1660100Notes

Reaction equation

HRID 1660100 reaction equation
[NH2:1][CH:2]([P:7]([OH:10])(=[O:9])[OH:8])[P:3]([OH:6])(=[O:5])[OH:4].[OH-].[Na+].[C:13]([OH:17])(=[O:16])[CH:14]=[CH2:15].Cl>O>[C:13]([CH2:14][CH2:15][NH:1][CH:2]([P:7]([OH:10])(=[O:8])[OH:9])[P:3]([OH:6])(=[O:4])[OH:5])([OH:17])=[O:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6581Acrylic Acid2×HCID 14798Sodium HydroxideHCID 34669(Aminomethylene)bisphosphonic acid

Product 1

HCID 86738161HCID 86738161, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

47.8 g. of aminomethane diphosphonic acid and 50 g. of sodium hydroxide are dissolved in 200 cc. of water. 19 g. Of acrylic acid dissolved in 50 cc. of water are added drop by drop thereto at a temperature between 20° C. and 40° C. while stirring vigorously. After the acrylic acid solution has been added, the reaction mixture is kept at a temperature of 90° C. for 30 minutes and is then neutralized with dilute hydrochloric acid. The neutralized solution is passed through a cation exchange agent and the resulting solution is concentrated by evaporation. After allowing the concentrated solution to stand for several days, N-(2-carboxy ethyl) amino methane diphosphonic acid is obtained in the form of crystals.

Workup

  1. concentrationthe resulting solution is concentrated by evaporation
  2. waitto stand for several days

Sources & evidence

ORD record
ord-2b35cc6e51264da1992ea15ad97b1196
Source dataset
uspto-grants-1981_12
Patent number
US04307038

Reaction notes

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