1,3-Dichloroacetone → HCID 131712621, compound

HRID 1660148Notes

Reaction equation

HRID 1660148 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[S:6][CH:7]=1.C(N)(=S)C1C=CC=CC=1.ClCC(CCl)=O.[Cl:29][C:30]1[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=1[CH:37]([OH:44])[CH2:38][N:39]1[CH:43]=[CH:42][N:41]=[CH:40]1>>[ClH:1].[Cl:29][C:30]1[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=1[CH:37]([O:44][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[S:6][CH:7]=1)[CH2:38][N:39]1[CH:43]=[CH:42][N:41]=[CH:40]1

Participants

5

Reactant 4

HCID 107931,3-DichloroacetoneHCID 32238(+-)-alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanolHCID 2369694-(Chloromethyl)-2-phenyl-1,3-thiazoleHCID 683563Thiobenzamide

Product 1

HCID 131712621HCID 131712621, compound

Procedure

Following the procedure of Example 1b, 4-chloromethyl-2-phenylthiazole (prepared according to Example 1a from thiobenzamide and 1,3-dichloroacetone, m.p. 134°-136° C. (absolute alcohol/ethylacetate), is reacted with 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol to obtain the title compound, m.p. 204°-205° C. (absolute alcohol/ethyl acetate).

Workup

  1. customprepared

Sources & evidence

ORD record
ord-51ec89eeee164a9d8824acfede225fd2
Source dataset
uspto-grants-1981_12
Patent number
US04307105

Reaction notes

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