Hydrogen Bromide → 2(3-Aminopropylthio)imidazole dihydrobromide

HRID 1660186Notes

Reaction equation

HRID 1660186 reaction equation
[SH:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[NH2:7][CH2:8][CH2:9][CH2:10]O.[BrH:12]>>[BrH:12].[BrH:12].[NH2:7][CH2:8][CH2:9][CH2:10][S:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 90863-Amino-1-propanolHCID 178527877HCID 178527877, compound

Product 1

HCID 205575842(3-Aminopropylthio)imidazole dihydrobromide

Procedure

A solution of 2-mercaptoimidazole (2 g.) and 3-aminopropanol (1.14 ml.) in hydrobromic acid (48%, 25 ml.) was heated under reflux for 25 hours. The reaction mixture was evaporated to dryness and the oily residual solid recrystallised twice from ethanol/ether to give 2-(3-aminopropylmercapto)imidazole dihydrobromide (3.55 g.) m.p. 160°-162°.

Workup

  1. temperatureunder reflux for 25 hours
  2. customThe reaction mixture was evaporated to dryness
  3. customthe oily residual solid recrystallised twice from ethanol/ether

Sources & evidence

ORD record
ord-bc58acc3a3004d8094b217fd2929605a
Source dataset
uspto-grants-1981_12
Patent number
US04307101

Reaction notes

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