反应详情

温度

25 °C

A mixture of 1,3,4,9-tetrahydro-1-methylpyrano[3,4-b]indole-1-methanamine(2.6 g, described in Example 3), triethylamine (1.34 g), cyclohexylcarbonyl chloride (1.94 g) and dry tetrahydrofuran (60 ml) is stirred at 25° C. for 18 hours, filtered and evaporated. The residue is crystallized from benzene-hexane to obtain the title compound (3.8 g); mp 174°-175° C.; nmr (CDCl3) δ 0.85-2.25 (m), 1.55 (s), 2.81 (m), 3.79 (m) , 4.00 (m), 5.96 (t), 6.9-7.2 (m) and 9.71 (s).

1. filtrationfiltered
2. customevaporated
3. customThe residue is crystallized from benzene-hexane