Sulfur trioxide → 2-(4-Methylphenyl)-2-sulphoacetyl chloride

HRID 1660510Notes

Reaction equation

HRID 1660510 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([Cl:11])=[O:10])=[CH:4][CH:3]=1.[S:12](=[O:15])(=[O:14])=[O:13]>ClCCl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([S:12]([OH:15])(=[O:14])=[O:13])[C:9]([Cl:11])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24682Sulfur trioxideHCID 27606342-(4-Methylphenyl)acetyl chloride

Product 1

HCID 205568052-(4-Methylphenyl)-2-sulphoacetyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 4-methylphenylacetyl chloride (1.69 g, 10 mmole) in dichloromethane (20 ml) was treated with a suspension of sulphur trioxide--dioxane complex (15 mmole) in dichloromethane. The mixture was stirred at room temperature for eighteen hours and evaporated.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-35d560aac5b84defb7eaee8375b6e182
Source dataset
uspto-grants-1981_12
Patent number
US04308259

Reaction notes

Loading…