反应详情

To a solution of 0.5N ethynylmagnesium bromide in tetrahydrofuran (100 mL) was added under N2 and stirring 3-ethoxy-2-cyclohexen-1-one (3.75 g, 26.8 mmol) in tetrahydrofuran (12.5 mL). The mixture was stirred at RT for 20 h when it was acidified with 1N HCl (200 mL). After stirring for 15 min the acidic phase was extracted with dichloromethane (5×50 mL). The combined organic extracts were washed with water (2×50 mL) and dried (MgSO4). Evaporation of the solvent gave an oil that was purified by column chromatography (silica, ethyl acetate/hexane 1:9) to yield a yellow oil, 2.71 g, 22.6 mmol, 84%). Analysis were in agreement with literature data.

1. stirringAfter stirring for 15 min the acidic phase
2. extractionwas extracted with dichloromethane (5×50 mL)
3. washThe combined organic extracts were washed with water (2×50 mL)
4. dry with materialdried (MgSO4)
5. customEvaporation of the solvent
6. customgave an oil that
7. customwas purified by column chromatography (silica, ethyl acetate/hexane 1:9)
8. customto yield a yellow oil, 2.71 g, 22.6 mmol, 84%)