Phenacyl bromide → Phenacyl thiocyanate

HRID 1660671Notes

Reaction equation

HRID 1660671 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[SiH4].[S-:12][C:13]#[N:14].[Na+]>C(O)C>[S:12]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4])[C:13]#[N:14]

Participants

5

Reactant 3

HCID 6259Phenacyl bromideHCID 23953SilaneHCID 516871Sodium thiocyanate

Product 1

HCID 219693Phenacyl thiocyanate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Bromoacetophenone-modified aminopropylsilylated glass surfaces (2.5×7.5 cm; Sigma, Silane-Prep™, S4651) (see Example 13) were coated with a 0.1M solution of sodium thiocyanate in ethanol and incubated for five hours at 50° C. The glass surfaces thus treated were then washed five times using respectively 30 mL of ethanol for 3 minutes each at room temperature. After washing three times for three minutes each using respectively 30 mL of DCM at room temperature, the glass surfaces were dried and stored at 4° C. until further use.

Workup

  1. additionThe glass surfaces thus treated
  2. washwere then washed five times
  3. customfor 3 minutes
  4. customat room temperature
  5. washAfter washing three times for three minutes each using respectively 30 mL of DCM at room temperature
  6. customthe glass surfaces were dried
  7. customstored at 4° C. until further use

Sources & evidence

ORD record
ord-6c69b8cd2f5d46608e9d805dbc1a368d
Source dataset
uspto-grants-2011_10
Patent number
US08029979B2

Reaction notes

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