反应详情

Add n-butyl lithium (2.5 M in hexanes, 174 mL, 0.43 mmol) to a stirred solution of 7-(1-ethyl-propyl)-3-(2-methoxymethyl-thiazol-5-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine (150 mg, 0.43 mmol) in THF (3 mL) at −78° C. Stir for 30 min and add N-chlorosuccinimide (87 mg, 0.653 mmol). Stir 30 min and then warm the reaction slowly to room temperature allowing the reaction to continue overnight. Quench the reaction by adding saturated ammonium chloride solution, extract with ethyl acetate, dry over sodium sulfate, filter, and concentrate to a residue. Purify by flash chromatography, eluting with hexanes/ethyl acetate (10/2) to give the title compound (7 mg). MS (APCI) m/z (35Cl) 379.3 (M+1)+.

1. stirringStir 30 min
2. temperaturewarm
3. customthe reaction slowly to room temperature
4. customthe reaction
5. waitto continue overnight
6. customQuench
7. customthe reaction
8. extractionextract with ethyl acetate
9. dry with materialdry over sodium sulfate
10. filtrationfilter
11. concentrationconcentrate to a residue
12. customPurify by flash chromatography
13. washeluting with hexanes/ethyl acetate (10/2)