Potassium Cyanide → HCID 59233930, compound

HRID 1661070Notes

Reaction equation

HRID 1661070 reaction equation
[C:1](/[C:3](=[C:9]1/[CH2:10][CH2:11][C:12]2[C:17]/1=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)/C(OCC)=O)#[N:2].[C-:19]#[N:20].[K+]>C(O)C.O>[C:1]([CH2:3][C:9]1([C:19]#[N:20])[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([F:18])[CH:16]=2)[CH2:11][CH2:10]1)#[N:2]

Participants

5

Reactant 2

HCID 9032Potassium CyanideHCID 68217632HCID 68217632, compound

Product 1

HCID 59233930HCID 59233930, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of (E)-ethyl 2-cyano-2-(6-fluoro-2,3-dihydro-1H-inden-1-ylidene)acetate (Prep44, 7.5 g, 0.03 mol) in ethanol (100 ml), a solution of KCN (4.65 g, 0.08 mol) in water (30 ml) was added. The mixture was warmed to 65° C., and stirred for 7 h.

Sources & evidence

ORD record
ord-bb6e6be71c764db59dfdccb83f26dbc8
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

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