Hydrochloric Acid → 1-(4-Fluoro-benzoyl)-piperidine-3-carboxylic acid hydrazide hydrochloride

HRID 1661165Notes

Reaction equation

HRID 1661165 reaction equation
C(OC([NH:8][NH:9][C:10]([CH:12]1[CH2:17][CH2:16][CH2:15][N:14]([C:18](=[O:26])[C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:27]>>[ClH:27].[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:18]([N:14]2[CH2:15][CH2:16][CH2:17][CH:12]([C:10]([NH:9][NH2:8])=[O:11])[CH2:13]2)=[O:26])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66618470N'-[1-(4-Fluoro-benzoyl)-piperidine-3-carbonyl]-hydrazinecarboxylic acid tert-butyl ester

Product 1

HCID 666184101-(4-Fluoro-benzoyl)-piperidine-3-carboxylic acid hydrazide hydrochlorideYield 100%

Procedure

N′-[1-(4-Fluoro-benzoyl)-piperidine-3-carbonyl]-hydrazinecarboxylic acid tert-butyl ester was dissolved in 8 ml of 4N HCl (dioxane solution). The resulting reaction mixture was stirred at R.T. for 1 h and concentrated to afford 0.88 g (100%) of 1-(4-Fluoro-benzoyl)-piperidine-3-carboxylic acid hydrazide hydrochloride as a white solid.

Workup

  1. customThe resulting reaction mixture
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d4442915d4de4dce9ab52b71642bf2c7
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

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