反应详情

To (2R,3R)-2-methyl-1-(methylsulfonyl)-3-phenylaziridine (38a, 0.03 g, 0.14 mmol) in THF (4 ml) was added 1-(4-Fluorophenyl)-1H-indazole-5-thiol (37c, 0.038 g, 0.16 mmol) and sodium hydride (5.11 mg, 0.21 mmol) on an ice bath with stirring. The ice bath was removed and the mixture was stirren at room temperature over night. The solvent was removed and the mixture was purified on HPLC. Yield 0.007 g (11%).

1. customThe ice bath was removed
2. waitthe mixture was stirren at room temperature over night
3. customThe solvent was removed
4. customthe mixture was purified on HPLC