HCID 57545209, compound → HCID 57545154, compound

HRID 1661525Notes

Reaction equation

HRID 1661525 reaction equation
[Si]([O:8][C:9]1[C:13]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][Cl:21])=[CH:17][C:12]=2[O:11][C:10]=1[C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=1)(C(C)(C)C)(C)C>Cl.O1CCOCC1>[Cl:21][CH2:20][CH2:19][O:18][C:16]1[CH:15]=[CH:14][C:13]2[C:9](=[O:8])[CH:10]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)[O:11][C:12]=2[CH:17]=1

Participants

4

Reactant 1

HCID 57545209HCID 57545209, compound

Product 1

HCID 57545154HCID 57545154, compoundYield 100.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

66.5 g (152 mmol) of 3-tert-butyldimethylsilyloxy-6-(2-chloroethoxy)-2-(4-chlorophenyl)benzofuran are dissolved in 500 ml of a 4 M hydrogen chloride solution in dioxane at RT under argon and stirred for 1.5 h. The mixture is concentrated to result in 49.2 g of a residue which is stored under argon and reacted further without purification.

Workup

  1. concentrationThe mixture is concentrated

Sources & evidence

ORD record
ord-68bae9bb9a4d484cb01bb54c2bc6509f
Source dataset
uspto-grants-2011_10
Patent number
US08030347B2

Reaction notes

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