反应详情

To a mixture of ethyl 5-formyl-4-methyl-1H-pyrrole-2-carboxylate (0.97 g) and DMF (10 ml) was added sodium hydride (0.23 g) under ice-cooling, followed by stirring at room temperature for 0.5 hour. To a reaction mixture was added methyl iodide under ice-cooling, followed by stirring at room temperature for 15 hours. To the reaction mixture was added water under ice-cooling, followed by stirring at room temperature. The solid precipitated was collected by filtration and washed with water to obtain ethyl 5-formyl-1,4-dimethyl-1H-pyrrole-2-carboxylate (1.0 g).

1. temperaturecooling
2. temperaturecooling
3. stirringby stirring at room temperature for 15 hours
4. temperaturecooling
5. stirringby stirring at room temperature
6. customThe solid precipitated
7. filtrationwas collected by filtration
8. washwashed with water