Pyrrolidine → Methyl 2'-fluoro-5'-(methyloxy)-2-(1-pyrrolidinylmethyl)-1,1'-biphenyl-4-carboxylate

HRID 1662464Notes

Reaction equation

HRID 1662464 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH2:20][N:21]1C[CH2:25][CH2:24][CH2:23][CH2:22]1.N1CCCC1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:12][C:11]=1[CH2:20][N:21]1[CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 57705872Methyl 2'-fluoro-5'-(methyloxy)-2-(1-piperidinylmethyl)-1,1'-biphenyl-4-carboxylate

Product 1

HCID 57705589Methyl 2'-fluoro-5'-(methyloxy)-2-(1-pyrrolidinylmethyl)-1,1'-biphenyl-4-carboxylate

Procedure

Compound 66.65A was synthesized using a procedure analogous to that used for 66.64A using pyrrolidine in place of piperidine. MS ESI (pos.) m/e: 344 (M+H)+.

Sources & evidence

ORD record
ord-ac5e085b30a9405484a5cdd988bc70ea
Source dataset
uspto-grants-2011_10
Patent number
US08030354B2

Reaction notes

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