HCID 57706140, compound → HCID 57705681, compound

HRID 1662516Notes

Reaction equation

HRID 1662516 reaction equation
[C:1]1([C:8]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>CCOC(C)=O.[Pd]>[CH:1]1([C:8]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH3:25])[CH:19]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 57706140HCID 57706140, compound

Product 1

HCID 57705681HCID 57705681, compoundYield 99.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of 78.8A (0.291 g, 0.86 mmol) in EtOAc (2.00 mL) at 23° C. was added palladium on carbon (0.092 g, 0.86 mmol). The reaction was placed under an atmosphere of hydrogen and stirred for four hours. The reaction was then concentrated in vacuo to yield 78.8B (0.290 g, 99% yield).

Workup

  1. concentrationThe reaction was then concentrated in vacuo

Sources & evidence

ORD record
ord-b933f304257f4789b85ef4bc70064168
Source dataset
uspto-grants-2011_10
Patent number
US08030354B2

Reaction notes

Loading…