反应详情

A 200 mL round bottom flask was charged with 83.18E (0.80 g, 1.9 mmol), MeOH (10 mL), and PPTS (0.047 g, 0.19 mmol). The solution was stirred overnight at room temperature and diluted with EtOAc. The organic phase was washed with water and brine, dried (MgSO4), and concentrated. The crude product was purified by silica gel flash chromatography (20-55% EtOAc/hexane) to afford 83.18F (0.52 g, 88%) as a colorless oil.

1. washThe organic phase was washed with water and brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. customThe crude product was purified by silica gel flash chromatography (20-55% EtOAc/hexane)