反应详情

To a stirred solution of 83.27A (0.800 g, 2.6 mmol) in THF (7.00 mL) and MeOH (7.00 mL) at 0° C. was slowly added potassium hydroxide (1.4 mL, 2.9 mmol) to maintain the temperature below 6° C. The reaction mixture was then allowed to warm to room temperature and stirred for 19 hours. The reaction was then acidified with 1N HCl and extracted three times with EtOAc. After drying over anhydrous magnesium sulfate and filtering, the organic solvent was removed under reduced pressure to yield 83.27B as a colorless solid (0.76 g, 100% yield).

1. customat 0° C.
2. temperatureto maintain the temperature below 6° C
3. extractionextracted three times with EtOAc
4. dry with materialAfter drying over anhydrous magnesium sulfate
5. filtrationfiltering
6. customthe organic solvent was removed under reduced pressure