Hydrochloric Acid → HCID 59867880, compound

HRID 1662725Notes

Reaction equation

HRID 1662725 reaction equation
Cl.C(OC(=O)[NH:8][CH:9]1[CH2:12][N:11]([C:13](=[O:56])[C@@H:14]2[CH2:18][C@@H:17]([OH:19])[CH2:16][N:15]2[C:20]2([C:47]3[CH:52]=[C:51]([CH3:53])[CH:50]=[CH:49][C:48]=3[O:54][CH3:55])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([Cl:29])[CH:27]=3)[N:22]([S:30]([C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][C:34]=3[O:41][C:42]([F:45])([F:44])[F:43])(=[O:32])=[O:31])[C:21]2=[O:46])[CH2:10]1)(C)(C)C.C([O-])(O)=O.[Na+]>>[NH2:8][CH:9]1[CH2:10][N:11]([C:13]([C@@H:14]2[CH2:18][C@@H:17]([OH:19])[CH2:16][N:15]2[C:20]2([C:47]3[CH:52]=[C:51]([CH3:53])[CH:50]=[CH:49][C:48]=3[O:54][CH3:55])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([Cl:29])[CH:27]=3)[N:22]([S:30]([C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][C:34]=3[O:41][C:42]([F:44])([F:45])[F:43])(=[O:31])=[O:32])[C:21]2=[O:46])=[O:56])[CH2:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59867868HCID 59867868, compound

Product 1

HCID 59867880HCID 59867880, compound

Procedure

Concentrated hydrochloric acid was added to 200 mg of compound obtained in Example 162, and the solution was stirred at room temperature for 30 minutes. The solution was poured into saturated NaHCO3 and the resulting mixture was extracted with EtOAc. The extract was dried over Na2SO4, then, the drying agent was separated by filtration and the solvent was evaporated under reduced pressure. The title compound in the amount of 144 mg (colorless amorphous) was obtained.

Workup

  1. extractionthe resulting mixture was extracted with EtOAc
  2. dry with materialThe extract was dried over Na2SO4
  3. customthe drying agent was separated by filtration
  4. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-5baf8333bc7f4f37b543fcb1792a8cc7
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

Loading…