Water → HCID 67428433, compound

HRID 1662727Notes

Reaction equation

HRID 1662727 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.[F:10][C:11]([F:15])([F:14])[CH2:12]I.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH2:12][C:11]([F:15])([F:14])[F:10])[CH:4]=1

Participants

6

Reactant 4

HCID 962WaterHCID 90073-MethoxyphenolHCID 10796Cesium carbonateHCID 677091,1,1-Trifluoro-2-iodoethane

Product 1

HCID 67428433HCID 67428433, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

A suspension of 5.00 g of 3-methoxy phenol, 10.0 g of 2,2,2-trifluoroethyl iodide and 20.0 g of cesium carbonate in DMF (15 ml) was stirred at 80° C. for two hours. The solution was added with water and extracted with Et2O; the organic layer was washed in saturated brine, then, was dried in MgSO4, the drying agent was separated by filtration and solvent was evaporated under reduced pressure obtained 6.60 g of the title compound.

Workup

  1. extractionextracted with Et2O
  2. washthe organic layer was washed in saturated brine
  3. dry with materialwas dried in MgSO4
  4. customthe drying agent was separated by filtration and solvent
  5. customwas evaporated under reduced pressure

Sources & evidence

ORD record
ord-08e4eaa9ee0642ac9eedeb85a0db9811
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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