Water → HCID 18736636, compound

HRID 1662728Notes

Reaction equation

HRID 1662728 reaction equation
CI.[F:3][CH:4]([F:13])[O:5][C:6]1[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=1.[C:14]([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[F:3][CH:4]([F:13])[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:14])[CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27741223-(difluoromethoxy)phenol

Product 1

HCID 18736636HCID 18736636, compoundYield 2,114.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.67 g of methyl iodide was stirred on ice in a suspension of 2.00 g of 3-difluoromethoxy phenol and 2.60 g of K2CO3 in DMF (10 ml) at room temperature for two hours. Water was added to the solution and the resulting mixture was extracted with Et2O; the organic layer was washed with saturated brine and then dried over MgSO4; the drying agent was separated by filtration, and the solvent was evaporated under reduced pressure obtained 46.0 g of the title compound (crude form).

Workup

  1. extractionthe resulting mixture was extracted with Et2O
  2. washthe organic layer was washed with saturated brine
  3. dry with materialdried over MgSO4
  4. customthe drying agent was separated by filtration
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-899b08c2cdff46f19bf6c95af998010d
Source dataset
uspto-grants-2011_10
Patent number
US08030499B2

Reaction notes

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