HRID1662753

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8021

Diethylamine

C4H11N

结构：COc1ccc(S(=O)(=O)N2C(=O)C(c3cc(C=O)ccc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC(F)(F)F)c1

HCID59867892

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)Cc1ccc(OC)c(C2(N3C[C@H](O)C[C@H]3C(=O)N(C)C)C(=O)N(S(=O)(=O)c3ccc(OC)cc3OC(F)(F)F)c3ccc(Cl)cc32)c1

HCID59867904

未命名化合物

PROCEDURE

实验过程

With 101 mg of the compound obtained in Step 204-7 and diethyl amine (18 μl) as starting material, 31.0 mg of the title compound (colorless amorphous) was obtained by a similar method to Step 195-1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35d8c1f8a91c4cca997dd0b458681fa6
来源数据集: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08030499B2
来源说明: uspto-grants-2011_10

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:26])([F:25])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([N:38]1[CH2:47][C@H:46]([OH:48])[CH2:45][C@H:39]1[C:40]([N:42]([CH3:44])[CH3:43])=[O:41])[C:28]1[CH:33]=[C:32]([CH:34]=O)[CH:31]=[CH:30][C:29]=1[O:36][CH3:37].[CH2:49]([NH:51][CH2:52][CH3:53])[CH3:50]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][C:23]([F:25])([F:26])[F:24])(=[O:13])=[O:12])[C:6](=[O:27])[C:5]2([N:38]1[CH2:47][C@H:46]([OH:48])[CH2:45][C@H:39]1[C:40]([N:42]([CH3:44])[CH3:43])=[O:41])[C:28]1[CH:33]=[C:32]([CH2:34][N:51]([CH2:52][CH3:53])[CH2:49][CH3:50])[CH:31]=[CH:30][C:29]=1[O:36][CH3:37]