Ethyl Glycolate → Ethyl [(phenoxycarbonyl)oxy]acetate

HRID 1663024Notes

Reaction equation

HRID 1663024 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:3].[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH2:12][OH:13].C(N(C(C)C)CC)(C)C>C1(C)C=CC=CC=1>[C:5]1([O:4][C:2]([O:13][CH2:12][C:11]([O:15][CH2:16][CH3:17])=[O:14])=[O:3])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 12184Ethyl GlycolateHCID 15891Phenyl chloroformateHCID 81531Diisopropylethylamine

Product 1

HCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

32 ml (256 mmol) of phenyl chloroformate are added slowly at room temperature to a solution of 25 g (240 mmol) of ethyl glycolate and 55 ml (315 mmol) of diisopropylethylamine in 500 ml of toluene. Stirring is continued at room temperature for 2 hours.

Sources & evidence

ORD record
ord-62397ecc60cb4a358d4ec6cb718ca81f
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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