Methylamine → HCID 58861255, compound

HRID 1663045Notes

Reaction equation

HRID 1663045 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18][N:19]3[C:23](=[O:24])[CH2:22][O:21][C:20]3=[O:25])[CH2:13][CH2:12]2)[N:2]=1.[CH3:26][NH2:27]>O1CCCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([N:11]2[CH2:12][CH2:13][CH:14]([CH2:17][CH2:18][NH:19][C:20](=[O:25])[O:21][CH2:22][C:23]([NH:27][CH3:26])=[O:24])[CH2:15][CH2:16]2)[N:2]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 21096960HCID 21096960, compound

Product 1

HCID 58861255HCID 58861255, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The process is performed according to the procedure described in Example 1 (step 1.5). Starting with 0.24 g (0.71 mmol) of 3-{2-[1-(3-isoquinolyl)-4-piperidyl]ethyl}-1,3-oxazolidine-2,4-dione, obtained in step 11.3, and 1.8 ml (3.53 mmol) of a solution (2M) of methylamine in tetrahydrofuran, and after chromatography on silica gel, eluting with a 98/2 and then 96/4 mixture of dichloromethane and methanol, followed by crystallization from diisopropyl ether, 0.16 g of pure product is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-a55eb2139db94f1887619b821f8851ed
Source dataset
uspto-grants-2011_10
Patent number
US08034818B2

Reaction notes

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