N-Hydroxyphthalimide → O-(2,6-Dichloro-pyridin-4-ylmethyl)-hydroxylamine hydrochloride

HRID 1663113Notes

Reaction equation

HRID 1663113 reaction equation
[OH:1][N:2]1C(=O)C2=CC=CC=C2C1=O.Br[CH2:14][C:15]1[CH:20]=[C:19]([Cl:21])[N:18]=[C:17]([Cl:22])[CH:16]=1>>[ClH:21].[Cl:21][C:19]1[CH:20]=[C:15]([CH2:14][O:1][NH2:2])[CH:16]=[C:17]([Cl:22])[N:18]=1

Participants

3

Reactant 2

HCID 10665N-HydroxyphthalimideHCID 27818294-(Bromomethyl)-2,6-dichloropyridine

Product 1

HCID 86615646O-(2,6-Dichloro-pyridin-4-ylmethyl)-hydroxylamine hydrochloride

Procedure

Prepared by a similar procedure as described for preparation 18. Starting materials: N-hydroxyphthalimide and 4-bromomethyl-2,6-dichloropyridin (Maybridge). 1H-NMR (DMSO-d6) δ 11.2 (br, 3H), 7.62 (s, 2H), 5.18 (s, 2H).

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation 18

Sources & evidence

ORD record
ord-ed5e4705eefd45daba55b4a84794e02a
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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