N-Hydroxyphthalimide → O-(5-Chloro-thiophen-2-ylmethyl)-hydroxylamine

HRID 1663120Notes

Reaction equation

HRID 1663120 reaction equation
[OH:1][N:2]1C(=O)C2=CC=CC=C2C1=O.[Cl:13][C:14]1[S:15][C:16]([CH2:19]Cl)=[CH:17][CH:18]=1>>[Cl:13][C:14]1[S:15][C:16]([CH2:19][O:1][NH2:2])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 10665N-HydroxyphthalimideHCID 5830792-Chloro-5-(chloromethyl)thiophene

Product 1

HCID 10986580O-(5-Chloro-thiophen-2-ylmethyl)-hydroxylamine

Procedure

Prepared by a similar procedure as described for preparation 15. Starting materials: N-hydroxyphthalimide and 2-chloro-5-(chloromethyl)thiophene (Aldrich). 13C-NMR (DMSO-d6) δ 140.2, 127.9, 126.3, 126.0, 71.1.

Workup

  1. customPrepared by a similar procedure
  2. customas described for preparation 15

Sources & evidence

ORD record
ord-03d2ae0217664db097dda48cb400b540
Source dataset
uspto-grants-2011_10
Patent number
US08034811B2

Reaction notes

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