Hydrochloric Acid → HCID 86613655, compound

HRID 1663589Notes

Reaction equation

HRID 1663589 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:28]2[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=2)[N:9]2[CH2:13][CH2:12][C@@H:11]([NH:14][C:15](=[O:27])[C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[CH2:10]2)=[CH:4][CH:3]=1.Cl>O.CO>[ClH:1].[Cl:34][C:31]1[CH:30]=[CH:29][C:28]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[N:9]2[CH2:13][CH2:12][C@@H:11]([NH:14][C:15](=[O:27])[C:16]3[CH:17]=[CH:18][C:19]([O:22][C:23]([F:24])([F:25])[F:26])=[CH:20][CH:21]=3)[CH2:10]2)=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67436302HCID 67436302, compound

Product 1

HCID 86613655HCID 86613655, compoundYield 198.3%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

To a solution of the compound obtained in Example 1 (64 mg) in water/methanol was added 6N HCl (21 μL) and the mixture was concentrated in vacuo to give (3R)-1[bis-(4-chlorophenyl)methyl]-3-[[4-(trifluoromethyloxy)benzoyl]amino]-pyrrolidine hydrochloride (68 mg, yield: 100%) as an amorphous powder.

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-89a4e79ca7434a80a9f713b77d4da4d9
Source dataset
uspto-grants-2011_10
Patent number
US08034949B2

Reaction notes

Loading…