反应详情

To a solution of 4-cyanobenzaldehyde (3.93 g) in tetrahydrofaran was added dropwise 1.0M 4-chlorophenylmagnesium bromide-diethylether (30 mL) under nitrogen gas atmosphere and cooling in dry ice/methanol bath and the mixture was stirred at the same temperature for 10 minutes. To the reaction mixture was added 10% HCl solution and the aqueous layer was extracted with ethyl acetate (×2). The organic layer was washed with a saturated brine, dried over magnesium sulfate and concentrated in vacuo. To the resultant crude product was added diisopropyl ether and the resultant solid materials were collected by filtration to give (4-chlorophenyl)(4-cyanophenyl)methanol (6.98 g, yield: 96%) as a pale yellow solid.

1. extractionthe aqueous layer was extracted with ethyl acetate (×2)
2. washThe organic layer was washed with a saturated brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated in vacuo
5. additionTo the resultant crude product was added diisopropyl ether
6. filtrationthe resultant solid materials were collected by filtration