Potassium Carbonate → HCID 58027728, compound

HRID 1664077Notes

Reaction equation

HRID 1664077 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].CN1C(=O)CCC1.[CH3:23][N:24]([CH3:30])[CH2:25][CH2:26][CH2:27][NH:28][CH3:29]>CC(C)=O>[CH3:23][N:24]([CH3:30])[CH2:25][CH2:26][CH2:27][N:28]([CH3:29])[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 680234-FluorobenzaldehydeHCID 783021,3-Propanediamine, N1,N1,N3-trimethyl-

Product 1

HCID 58027728HCID 58027728, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
50 °C

Procedure

10 g of 4-fluorobenzaldehyde, 12 g of K2CO3 and 20 ml of NMP are stirred and heated at 50° C. 13 ml of N,N,N′-trimethyl-1,3-propanediamine are added dropwise to the medium kept stirring and heated at 80° C. for 10 h. After the reaction medium has been cooled to ambient temperature, 100 ml of acetone are added. The precipitate obtained is filtered off, and the filtrate is evaporated to dryness and then dried. 21.85 g of powder are recovered. The analyses indicate that the product is in conformity.

Workup

  1. temperatureheated at 80° C. for 10 h
  2. temperatureAfter the reaction medium has been cooled to ambient temperature
  3. customThe precipitate obtained
  4. filtrationis filtered off
  5. customthe filtrate is evaporated to dryness
  6. customdried
  7. custom21.85 g of powder are recovered

Sources & evidence

ORD record
ord-c1b0407cb9834d9bb354d87fd44e98df
Source dataset
uspto-grants-2011_10
Patent number
US08038732B2

Reaction notes

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