Hydroxylamine → HCID 178513392, compound

HRID 1664198Notes

Reaction equation

HRID 1664198 reaction equation
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1([C:12]#[N:13])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.[NH2:14][OH:15]>>[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]1([C:12](=[NH:13])[NH:14][OH:15])[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 67439994HCID 67439994, compound

Product 1

HCID 178513392HCID 178513392, compoundYield 84%

Procedure

Reaction of 4-((2-chloroethoxy)methyl)tetrahydro-2H-pyran-4-carbonitrile (10.78 g, 52.9 mmol) with hydroxylamine gave 10.59 g (84% yield) of the title material as a white solid. 1HNMR 400 MHz (CDCl3) δ (ppm): 1.60 (2H, m, CH2), 2.04 (2H, m, CH2), 3.52 (2H, s, CH2), 3.55-3.85 (8H, m, 4×CH2), 5.01 (2H, broad s). MS (ESI+) m/e 237 [M+H+].

Sources & evidence

ORD record
ord-3a631430cb254258bdac21b4b38bdde6
Source dataset
uspto-grants-2011_10
Patent number
US08039458B2

Reaction notes

Loading…