Hydrochloric Acid → HCID 22975579, compound

HRID 1664811Notes

Reaction equation

HRID 1664811 reaction equation
Cl.[O:2]=[C:3]1[C:7]2([CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[N:6]=[CH:5][NH:4]1>O1CCOCC1>[N:6]1[C:7]2([CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[C:3](=[O:2])[NH:4][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67440963HCID 67440963, compound

Product 1

HCID 22975579HCID 22975579, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrochloric acid (4.0 N in dioxane; 4 mL, 16.0 mmol) was added to a solution of tert-butyl 4-oxo-1,3,8-triazaspiro[4.5]dec-1-ene-8-carboxylate (60 mg, 0.24 mmol) in dioxane (6 mL). After 18 h, the reaction mixture was concentrated to give the hydrochloride salt of the title compound. MS 154.1 (M+1).

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-8c6739a2dfeb4380b37ed010b7100f62
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

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