Hydrochloric Acid → HCID 67440367, compound

HRID 1664870Notes

Reaction equation

HRID 1664870 reaction equation
Cl.[F:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C@H:10]1[CH2:16][N:15]2[C:17]([CH:20]3[CH2:24][CH2:23][O:22][CH2:21]3)=[CH:18][N:19]=[C:14]2[C@H:13]([NH:25]C(=O)OC(C)(C)C)[CH2:12][CH2:11]1>O1CCOCC1>[F:2][C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C@H:10]1[CH2:16][N:15]2[C:17]([CH:20]3[CH2:24][CH2:23][O:22][CH2:21]3)=[CH:18][N:19]=[C:14]2[C@H:13]([NH2:25])[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86620135HCID 86620135, compound

Product 1

HCID 67440367HCID 67440367, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Hydrochloric acid (4.0 M in dioxane; 3 mL, 12.0 mmol) was added to a solution of tert-butyl [(6S,9R)-6-(2,3-difluorophenyl)-3-(tetrahydrofuran-3-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-9-yl]carbamate (113 mg, 0.261 mmol) in 1,4-dioxane (3 mL). After 2.5 h, the reaction was concentrated to give the title compound as a bis hydrochloride salt (117 mg). MS 334.2 (M+1).

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-129a77e1de2a4558841805ac737cc259
Source dataset
uspto-grants-2011_10
Patent number
US08039460B2

Reaction notes

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