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HRID1665018

反应详情

EQUATION

反应方程式

HRID 1665018 的结构方程式

REACTANTS

反应物

3
结构：CC(C)CBr
HCID6555

1-Bromo-2-methylpropane

C4H9Br

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CS(=O)(=O)c1cccc(-c2ccc(CNS(=O)(=O)c3cccc(Cl)c3)s2)c1
HCID67442144

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CN(Cc1ccc(-c2cccc(S(C)(=O)=O)c2)s1)S(=O)(=O)c1cccc(Cl)c1
HCID25234384

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

In analogy to example 1, step 2, 3-chloro-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide (example 7, step 2) was reacted with sodium hydride in N,N-dimethylacetamide at 0° C. followed by reaction with 1-bromo-2-methylpropane at r.t. overnight to give 3-chloro-N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-benzenesulfonamide as a colorless solid. MS: 515.3 ([M+NH4]+)