Ethanesulfonyl chloride → HCID 25234392, compound

HRID 1665034Notes

Reaction equation

HRID 1665034 reaction equation
[CH2:1]([NH:5][CH2:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:13]=2)=[CH:10][CH:11]=1)[CH:2]([CH3:4])[CH3:3].[CH2:22]([S:24](Cl)(=[O:26])=[O:25])[CH3:23].C(N(CC)C(C)C)(C)C>ClCCl>[CH2:1]([N:5]([CH2:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:13]=2)=[CH:10][CH:11]=1)[S:24]([CH2:22][CH3:23])(=[O:26])=[O:25])[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 11667Ethanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 67441398Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine

Product 1

HCID 25234392HCID 25234392, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with ethanesulfonyl chloride and N,N-diisopropyl ethyl amine in dichloromethane to give ethanesulfonic acid isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amide as a light yellow oil. MS: 433.4 ([M+NH4]+)

Sources & evidence

ORD record
ord-bce458d7c0dc478991c59d97e2731b67
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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