Diisopropylethylamine → HCID 25235120, compound

HRID 1665037Notes

Reaction equation

HRID 1665037 reaction equation
[CH2:1]([NH:5][CH2:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:13]=2)=[CH:10][CH:11]=1)[CH:2]([CH3:4])[CH3:3].[CH3:22][O:23][C:24](=[O:35])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31](Cl)(=[O:33])=[O:32].C(N(CC)C(C)C)(C)C>ClCCl>[CH3:22][O:23][C:24](=[O:35])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31](=[O:32])(=[O:33])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[CH2:6][C:7]1[S:8][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([CH3:21])(=[O:20])=[O:19])[CH:13]=2)=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 117830Benzoic acid, 2-(chlorosulfonyl)-, methyl esterHCID 67441398Isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine

Product 1

HCID 25235120HCID 25235120, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In analogy to example 13, step 2, isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-amine (example 15, step 2) was reacted with methyl-2-(chlorosulfonyl)-benzoate and N,N-diisopropyl ethyl amine in dichloromethane to give 2-{isobutyl-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-sulfamoyl}-benzoic acid methyl ester as a colorless oil. MS: 522.3 ([M+H]+)

Sources & evidence

ORD record
ord-9165077e29bf4142b2cf607154b197a3
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

Loading…