Isobutyl iodide → HCID 25234245, compound

HRID 1665049Notes

Reaction equation

HRID 1665049 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:11]2[S:15][C:14]([CH2:16][NH:17][S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:29])[F:28])(=[O:20])=[O:19])=[CH:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH2:31](I)[CH:32]([CH3:34])[CH3:33].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C(=O)C>[CH2:31]([N:17]([CH2:16][C:14]1[S:15][C:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=2)=[CH:12][CH:13]=1)[S:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]([F:30])([F:28])[F:29])(=[O:20])=[O:19])[CH:32]([CH3:34])[CH3:33]

Participants

5

Reactant 3

HCID 10556Isobutyl iodideHCID 10796Cesium carbonateHCID 67440497HCID 67440497, compound

Product 1

HCID 25234245HCID 25234245, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to example 10, step 3, N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-2-trifluoromethyl-benzenesulfonamide (example 27, step 1) was reacted with isobutyl iodide and cesium carbonate in N,N-dimethylacetamide to give N-isobutyl-N-[5-(3-methanesulfonyl-phenyl)-thiophen-2-ylmethyl]-2-trifluoromethyl-benzenesulfonamide as a colorless solid. MS: 548.8 ([M+NH4]+)

Sources & evidence

ORD record
ord-a066800ab4ef45329be2117480c842a8
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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