Isobutyl iodide → HCID 25234317, compound

HRID 1665077Notes

Reaction equation

HRID 1665077 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][NH:18][S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])[CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].I[CH2:26][CH:27]([CH3:29])[CH3:28].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C(=O)C>[CH2:26]([N:18]([CH2:17][C:13]1[CH:12]=[C:11]([C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=2)[CH:16]=[CH:15][CH:14]=1)[S:19]([CH:22]([CH3:24])[CH3:23])(=[O:20])=[O:21])[CH:27]([CH3:29])[CH3:28]

Participants

5

Reactant 3

HCID 10556Isobutyl iodideHCID 10796Cesium carbonateHCID 67438422HCID 67438422, compound

Product 1

HCID 25234317HCID 25234317, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to example 10, step 3, propane-2-sulfonic acid (3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide (example 49, step 2) was reacted with 1-iodo-2-methylpropane and cesium carbonate in N,N-dimethylacetamide to give propane-2-sulfonic acid isobutyl-(3′-methanesulfonyl-biphenyl-3-ylmethyl)-amide as an off-white solid. MS: 441.3 ([M+NH4]+)

Sources & evidence

ORD record
ord-f82e80f5bc674b2d9286718bc7ba5228
Source dataset
uspto-grants-2011_10
Patent number
US08039493B2

Reaction notes

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