4-Aminobiphenyl → Formamide, N-(1,1'-biphenyl)-4-yl-

HRID 1665678Notes

Reaction equation

HRID 1665678 reaction equation
[C:1]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][C:4]([NH2:7])=[CH:3][CH:2]=1.[CH2:14]([O:16]C=O)C>>[C:1]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:2]=[CH:3][C:4]([NH:7][CH:14]=[O:16])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 71024-AminobiphenylHCID 8025Ethyl formate

Product 1

HCID 95684Formamide, N-(1,1'-biphenyl)-4-yl-Yield 86.2%

Procedure

A mixture of biphenyl-4-ylamine (100 mg, 0.59 mmol) and ethylformate (1 mL) was stirred at reflux temperature for 1 hr. After the completion of the reaction, the reaction mixture was quenched with cold water. The precipitate was filtered to afford 100 mg (86.2% Yield) of N-biphenyl-4-yl-formamide as the required product.

Workup

  1. temperatureat reflux temperature for 1 hr
  2. customAfter the completion of the reaction
  3. customthe reaction mixture was quenched with cold water
  4. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-830b7b86db6041399a8280fc346fdbba
Source dataset
uspto-grants-2011_10
Patent number
US08039463B2

Reaction notes

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