2-Fluoropyridine → HCID 24947346, compound

HRID 1665828Notes

Reaction equation

HRID 1665828 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].F[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[F:26])[CH2:21]Br>>[F:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[F:26])[CH2:21][N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]1=[N:5][C:4]1[CH:6]=[CH:7][C:8]([F:9])=[C:2]([F:1])[CH:3]=1

Participants

4

Reactant 3

HCID 97462-FluoropyridineHCID 774693,4-DifluoroanilineHCID 5814364-(Bromomethyl)-1,2-difluorobenzene

Product 1

HCID 24947346HCID 24947346, compound

Procedure

The title compound was prepared in four steps from 3,4-difluoroaniline, 2-fluoropyridine and 3,4-difluorobenzyl bromide as described in Procedure B. The crude product was purified by preparative LC-MS to give the title compound as the free base (yellowish solid). MS (ES+) m/z 333 ([M+1]+, 100); HR-MS: 333.1008 ([M+1]+, C18H13F4N2; calc. 333.101485).

Workup

  1. customThe crude product was purified by preparative LC-MS

Sources & evidence

ORD record
ord-e2b96e7b50f847fba8ce9ad51fce2da6
Source dataset
uspto-grants-2011_10
Patent number
US08039632B2

Reaction notes

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